Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …

The ETS family of transcription factors are evolutionarily conserved throughout the metazoan
lineage and are critical for regulating cellular processes such as proliferation, differentiation …

Gene expression is regulated by the complex interaction between transcriptional activators
and repressors, which function in part by recruiting histone-modifying enzymes to control …

The subdivision of cell populations in compartments is a key event during animal
development. In Drosophila, the gene apterous (ap) divides the wing imaginal disc in dorsal …

The acquisition of cellular identity during development depends on precise spatiotemporal
regulation of gene expression, with combinatorial interactions between transcription factors …

Cis-regulatory modules (CRMs) are defined by unique combinations of transcription factor-
binding sites. Emerging evidence suggests that the number, affinity, and organization of …

Cebpa encodes a transcription factor (TF) that plays an instructive role in the development of
multiple myeloid lineages. The expression of Cebpa itself is finely modulated, as Cebpa is …

For coordinated circulation, vertebrate and invertebrate hearts require stereotyped
arrangements of diverse cell populations. This study explores the process of cardiac cell …

Dense genotyping approaches have revealed much about the genetic architecture both of
gene expression and disease susceptibility. However, assigning causality to genetic …

Pleiotropic signaling pathways must somehow engender specific cellular responses. In the
Drosophila mesoderm, Ras pathway signaling specifies muscle founder cells from among …