Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls

F Bavato, C Barro, LK Schnider, J Simrén… - Molecular …, 2024 - nature.com
The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …

[HTML][HTML] Neurofilament light and glial fibrillary acidic protein in mood and anxiety disorders: A systematic review and meta-analysis

MJY Kang, J Grewal, D Eratne, C Malpas… - Brain, Behavior, and …, 2024 - Elsevier
Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are biomarkers of
neuronal injury measurable in cerebrospinal fluid (CSF) and blood. Despite their potential …

Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders

D Eratne, M Kang, C Malpas… - Australian & New …, 2024 - journals.sagepub.com
Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show
promise to improve diagnosis of neurodegenerative disorders and distinguish …

Plasma neurofilament light chain in association to late‐life depression in the general population

IK Schuurmans, M Ghanbari, CAM Cecil… - Psychiatry and …, 2024 - Wiley Online Library
Aim Investigating what is underlying late‐life depression is becoming increasingly important
with the rapidly growing elderly population. Yet, the associations between plasma …

Neurofilament light chain as a promising biomarker for depression diagnosis: a systematic review and meta-analysis

A Habibzadeh, VR Ostovan, MA Ghezel, K Kavari… - BMC psychiatry, 2024 - Springer
Background Depression is a prevalent and serious mental health disorder that significantly
impacts daily life and functioning. Neurofilament Light chain (NfL), associated with axonal …

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

WY Chen, MC Huang, CC Chiu, YC Cheng, CJ Kuo… - BJPsych …, 2022 - cambridge.org
Background Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low
serum vitamin D levels are significantly associated with compromised cognition in …

[HTML][HTML] Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder …

CMJ Wannan, D Eratne, AF Santillo, C Malpas… - Psychiatry …, 2024 - Elsevier
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study
examined whether relationships between age and plasma neurofilament light (NfL) protein …

Procollagen type 1 N-terminal propeptide, neurofilament light chain, proinflammatory cytokines, and cognitive function in bipolar and major depressive disorders: An …

YM Bai, YL Liu, HW Kuo, SJ Tsai, JW Hsu… - Journal of Psychiatric …, 2023 - Elsevier
Background Higher levels of neurofilament light chain (NfL) and proinflammatory cytokines
(ie, tumor necrosis factor [TNF]-α) were observed in patients with bipolar disorder (BD) and …

The multifaceted role of neurofilament light chain protein: emerging opportunities in primary psychiatric conditions

F Bavato, E Seifritz, BB Quednow - Brain, 2024 - academic.oup.com
It was with great interest that we read the article by Abu-Rumeileh et al. 1 entitled 'The
multifaceted role of neurofilament light chain protein in non-primary neurological diseases' …

A longitudinal investigation of blood neurofilament light chain levels in chronic cocaine users

F Bavato, AK Kexel, B Kluwe-Schiavon, A Maceski… - Molecular …, 2023 - Springer
The identification of a blood marker of brain pathology that is sensitive to substance-induced
neurotoxicity and dynamically responds to longitudinal changes in substance intake would …