3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …

Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

The emergence and convergence of cancer genomics, targeted therapies, and network
oncology have significantly expanded the landscape of protein–protein interaction (PPI) …

Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …

Regulation of inflammation is a central part of the maintenance of homeostasis by the
immune system. One important class of regulatory protein that has been shown to have …

A specific α-aminophosphonate molecule, namely diethyl (phenyl (4-pyridinylamino) methyl)
phosphonate (α-DAP), as a potential SARS-CoV-2 inhibitor, has been synthesized via a …

14-3-3 proteins are a family of proteins expressed throughout the body and implicated in
many diseases, from cancer to neurodegenerative disorders. While these proteins do not …

Rationale: The 14-3-3 protein family is known to interact with many proteins in non-cardiac
cell types to regulate multiple signaling pathways, particularly those relating to energy and …

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-
protein interactions (PPIs). They are usually found in all eukaryotes with a conserved …

Small-molecule modulation of protein–protein interactions (PPIs) is one of the most exciting
but also difficult fields in chemical biology and drug development. As one of the most …