Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Background Natalizumab is the first α4 integrin antagonist in a new class of selective
adhesion-molecule inhibitors. We report the results of a two-year phase 3 trial of …

Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …

Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory
and autoimmune diseases, and it is specifically localized in and around inflammatory cells …

Although recent data suggests that osteoblasts play a key role within the hematopoietic stem
cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies …

Stem cells reside in a specialized niche that regulates their abundance and fate.
Components of the niche have generally been defined in terms of cells and signaling …

Osteopontin is a secreted glycoprotein with a multidomain structure and functions
characteristic of a matricellular protein. Osteopontin interacts with cell surface receptors via …

The litter-bearing pig is an invaluable model for research in reproductive biology. Spherical
pig blastocysts on Day 10 of pregnancy undergo rapid morphological changes to tubular …