The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …

Accurate chromosome segregation is vital for cell and organismal viability. The mitotic
spindle, a bipolar macromolecular machine composed largely of dynamic microtubules, is …

Accurate genome segregation in mitosis requires that all chromosomes are bioriented on
the spindle. Cells monitor biorientation by sensing tension across sister centromeres …

During mitosis, sister chromatids are stretched apart at their centromeres via their
attachment to oppositely oriented kinetochore microtubules. This stretching generates …

Genome haploidization involves sequential loss of cohesin from chromosome arms and
centromeres during two meiotic divisions. At centromeres, cohesin's Rec8 subunit is …

As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated
kinase 2 (PAK2) participates in diverse biologic events. However, its roles in mouse oocyte …

Simple Summary Chromosome instability (CIN) promotes cancer initiation and progression,
but its genetic origins remain largely unknown. As aberrant mitotic processes such as …

The microtubule (MT)-stabilizing drug Taxol (paclitaxel) is a commonly used tool to
investigate MT dynamics and MT-dependent processes. Here, we present a protocol for …

Avian reoviruses (ARV) are a group of poultry pathogens that cause runting and stunting
syndrome (RSS), a condition otherwise known as “frozen chicken”, which are characterized …

Over the last 30 years, computational biologists have developed increasingly realistic
mathematical models of the regulatory networks controlling the division of eukaryotic cells …