The druggability of solute carriers

WW Wang, L Gallo, A Jadhav, R Hawkins… - Journal of medicinal …, 2019 - ACS Publications
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …

Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives

Z Tashrifi, M Mohammadi-Khanaposhtani… - Molecular Diversity, 2020 - Springer
Amino-3-cyano-4 H-chromenes are structural core motifs that received increasing attention
in the last years due to their interesting potential pharmacological properties. In this review …

Identification of a new class of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors followed by a structure–activity relationship study

SW Hansen, MN Erichsen, B Fu… - Journal of Medicinal …, 2016 - ACS Publications
Screening of a small compound library at the three excitatory amino acid transporter
subtypes 1–3 (EAAT1–3) resulted in the identification of compound (Z)-4-chloro-3-(5-((3-(2 …

Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH‐102

I Haym, THV Huynh, SW Hansen… - …, 2016 - Wiley Online Library
Although the selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor UCPH‐
101 has become a standard pharmacological tool compound for in vitro and ex vivo studies …

Glutamate Transporter Functional Studies and Efflux Inhibitor Design

LJ Zielewicz - 2021 - search.proquest.com
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
concentration is maintained at a nanomolar to low micromolar concentration in the synaptic …

[PDF][PDF] Синтез нових карбанельованих похідних 4-арил-2-аміно-3-ціанопірану

ДВ Левашов, КМ Ситнік, КМ Сытник, ЛА Шемчук… - 2019 - researchgate.net
2-Аміно-4H-пірани є перспективним класом хімічних сполук, що активно досліджуються
ще з середини минулого століття. Серед синтетичних похідних даної гетероциклічної …