Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

[HTML][HTML] Cell segmentation methods for label-free contrast microscopy: review and comprehensive comparison

T Vicar, J Balvan, J Jaros, F Jug, R Kolar, M Masarik… - BMC …, 2019 - Springer
Background Because of its non-destructive nature, label-free imaging is an important
strategy for studying biological processes. However, routine microscopic techniques like …

White-light diffraction tomography of unlabelled live cells

T Kim, R Zhou, M Mir, SD Babacan, PS Carney… - Nature …, 2014 - nature.com
We present a technique called white-light diffraction tomography (WDT) for imaging
microscopic transparent objects such as live unlabelled cells. The approach extends …

Live-cell mass profiling: an emerging approach in quantitative biophysics

TA Zangle, MA Teitell - Nature methods, 2014 - nature.com
Cell mass, volume and growth rate are tightly controlled biophysical parameters in cellular
development and homeostasis, and pathological cell growth defines cancer in metazoans …

Quantitative phase imaging

M Mir, B Bhaduri, R Wang, R Zhu, G Popescu - Progress in optics, 2012 - Elsevier
Quantitative phase imaging (QPI) is an emerging field aimed at studying weakly scattering
and absorbing specimens (Popescu, 2011). The main challenge in generating intrinsic …

[HTML][HTML] Multimodal holographic microscopy: distinction between apoptosis and oncosis

J Balvan, A Krizova, J Gumulec, M Raudenska… - PloS one, 2015 - journals.plos.org
Identification of specific cell death is of a great value for many scientists. Predominant types
of cell death can be detected by flow-cytometry (FCM). Nevertheless, the absence of cellular …

Single-exposure quantitative phase imaging in color-coded LED microscopy

W Lee, D Jung, S Ryu, C Joo - Optics Express, 2017 - opg.optica.org
We demonstrate single-shot quantitative phase imaging (QPI) in a platform of color-coded
LED microscopy (cLEDscope). The light source in a conventional microscope is replaced by …

Breast cancer diagnosis using spatial light interference microscopy

H Majeed, ME Kandel, K Han, Z Luo… - … of biomedical optics, 2015 - spiedigitallibrary.org
The standard practice in histopathology of breast cancers is to examine a hematoxylin and
eosin (H&E) stained tissue biopsy under a microscope to diagnose whether a lesion is …

3D-printed pHEMA materials for topographical and biochemical modulation of dorsal root ganglion cell response

A Badea, JM McCracken, EG Tillmaand… - … applied materials & …, 2017 - ACS Publications
Understanding and controlling the interactions occurring between cells and engineered
materials are central challenges toward progress in the development of biomedical devices …

Label-free, ultrahigh-speed, 3D observation of bidirectional and correlated intracellular cargo transport by coherent brightfield microscopy

YF Huang, GY Zhuo, CY Chou, CH Lin, CL Hsieh - Nanoscale, 2017 - pubs.rsc.org
The investigation of intracellular transport at the molecular scale requires measurements at
high spatial and temporal resolutions. We demonstrate the label-free, direct imaging and …