microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA
molecules direct the addition of DNA methylation to specific DNA sequences. The RdDM …

Understanding genomic functions requires site-specific manipulation of loci via efficient
protein effector targeting systems. However, few approaches for targeted manipulation of the …

RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic
pathway in plants. RdDM requires a specialized transcriptional machinery that comprises …

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …

MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …

RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene
silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is …

MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …