Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Mammalian development requires effective mechanisms to repress genes whose
expression would generate inappropriately specified cells. The Polycomb-repressive …

In eukaryotes, three-dimensional genome organization is critical for transcriptional
regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin …

RNA plays a well-established architectural role in the formation of membraneless
interchromatin nuclear bodies. However, a less well-known role of RNA is in organizing …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

Long noncoding RNAs (lncRNAs) are transcripts over 200 base pairs in length with no
discernible protein-coding potential. Multiple lines of evidence point to lncRNAs as master …

Long non-coding RNAs (lncRNAs) have gained increasing attention as they exhibit highly
tissue-and cell-type specific expression patterns. LncRNAs are highly expressed in the …

Long non‐coding RNAs (lncRNAs) are RNAs that exceed 200 nucleotides in length and that
are not translated into proteins. Thousands of lncRNAs have been identified with functions in …

The compositional complexity of Polycomb Repressive Complex 1 (PRC1) increased
dramatically during vertebrate evolution. What is considered the “canonical” PRC1 complex …