This article provides an overview of studies addressing effects of ionizing radiation on the
heart. Clinical studies have identified early and late manifestations of radiation-induced …

Radiation‐induced myocardial fibrosis (RIMF) is a potentially lethal clinical complication of
chest radiotherapy (RT) and a final stage of radiation‐induced heart disease (RIHD). RIMF is …

Cancer management has undergone significant improvements, which led to increased long-
term survival rates among cancer patients. Radiotherapy (RT) has an important role in the …

Background and purpose The effects of radiation on the heart are dependent on dose,
fractionation, overall treatment time, and pre-existing cardiovascular pathology. Murine …

In addition to cytostatic treatment and surgery, the most common cancer treatment is gamma
radiation. Despite sophisticated radiological techniques however, in addition to irradiation of …

Radiation therapy (RT) for the treatment of thoracic tumors causes radiation-induced heart
disease (RIHD). Radiation-induced myocardial fibrosis (RIMF) is both an acute and chronic …

Cardiovascular disorders are among the critical side effects of cancer therapy. Damage to
the function and normal structure of the heart can cause serious threats to patients that are …

Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the
multimodal treatment of thoracic cancers. Due to significant improvements in overall cancer …

Pharmacological mitigation of injuries caused by high-dose ionizing radiation is an unsolved
medical problem. A specific nonlipid agonist of the type 2 G protein coupled receptor for …

Background: Advances in radiotherapy for thoracic cancers have resulted in improvement of
survival. However, radiation exposure to the heart can induce cardiotoxicity. No therapy is …