Statins are a group of lipid-lowering drugs that inhibit cholesterol biosynthesis and have anti-
inflammatory, anti-tumor, and immunomodulatory properties. Several lines of evidence …

In this review, steroids with a tertiary butyl group, which are usually called neo steroids, are a
small group of natural lipids isolated from higher plants, fungi, marine sponges, and yeast. In …

Statins are some of the most widely used drugs worldwide, but one of their major side effects
is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell …

HMG-CoA reductase inhibitors, or statins, are potent plasma LDL-cholesterol (LDL-c)
lowering agents. Since the introduction of the first statin, lovastatin, in 1987, accumulating …

Increasing evidence suggested that cholesterol is an important integrant of cell membranes,
that plays a key role in tumor progression, immune dysregulation, and pathological changes …

Background Primary and posttreatment resistance to BRAFV600 mutation–targeting
inhibitors leads to disease relapse in a majority of melanoma patients. In many instances …

Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, have been widely
used to lower cholesterol and prevent cardiovascular diseases. Recent preclinical and …

Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties,
affecting among others T cell activation and differentiation, antigen presentation, and …

The inhibition of mevalonate kinase (MVK) by downstream metabolites is an important
mechanism in the regulation of isoprenoid production in a broad range of organisms. The …

The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …