High-throughput screening: today's biochemical and cell-based approaches

V Blay, B Tolani, SP Ho, MR Arkin - Drug Discovery Today, 2020 - Elsevier
Highlights•Self-contained overview of current high-throughput screening technologies.•
Expands on the current use of most recent tools, like high-throughput microscopy.•Learn …

Single-cell droplet microfluidics for biomedical applications

D Liu, M Sun, J Zhang, R Hu, W Fu, T Xuanyuan, W Liu - Analyst, 2022 - pubs.rsc.org
Single-cell manipulation and analysis is critical to the study of many fundamental biological
processes and uncovering cellular heterogeneity, and presents the potential for extremely …

Accelerating organic solar cell material's discovery: high-throughput screening and big data

X Rodríguez-Martínez, E Pascual-San-José… - Energy & …, 2021 - pubs.rsc.org
The discovery of novel high-performing materials such as non-fullerene acceptors and low
band gap donor polymers underlines the steady increase of record efficiencies in organic …

[HTML][HTML] Emerging trends in organ-on-a-chip systems for drug screening

Y Wang, Y Gao, Y Pan, D Zhou, Y Liu, Y Yin… - … Pharmaceutica Sinica B, 2023 - Elsevier
New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …

Ultrasonic coupled abrasive jet polishing (UC-AJP) of glass-based micro-channel for micro-fluidic chip

J Ge, Y Ren, C Li, Z Li, S Yan, P Tang, X Xu… - International Journal of …, 2023 - Elsevier
The efficiency of abrasive jet polishing (AJP) is relatively low for glass-based micro-
channels, and an ultrasonic coupled AJP (UC-AJP) approach was thus proposed. The fluid …

Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics

J Zhai, C Li, H Li, S Yi, N Yang, K Miao, C Deng, Y Jia… - Lab on a Chip, 2021 - pubs.rsc.org
Microfluidics has been the most promising platform for drug screening with a limited number
of cells. However, convenient on-chip preparation of a wide range of drug concentrations …

Microfluidic nanodevices for drug sensing and screening applications

A Pal, K Kaswan, SR Barman, YZ Lin, JH Chung… - Biosensors and …, 2023 - Elsevier
The outbreak of pandemics (eg, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging …

Recent advances in cell membrane-coated technology for drug discovery from natural products

Y Bu, Q Hu, T Bao, X Xie, S Wang - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Natural products and their derivatives are a rich source for drug discovery. Meanwhile, cell
membrane has emerged as an effective tool to screen the active compounds from natural …

A magnetically controlled microfluidic device for concentration dependent in vitro testing of anticancer drug

VK Yadav, P Ganguly, P Mishra, S Das, D Mallick - Lab on a Chip, 2023 - pubs.rsc.org
Compartmentalizing magnetically controlled drug molecules is critical in several
bioanalytical trials and tests, such as drug screening, digital PCR, magnetic hyperthermia …

Acoustofluidic droplet sorter based on single phase focused transducers

R Zhong, S Yang, GS Ugolini, T Naquin, J Zhang… - Small, 2021 - Wiley Online Library
Droplet microfluidics has revolutionized the biomedical and drug development fields by
allowing for independent microenvironments to conduct drug screening at the single cell …