Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

The extracellular matrix regulates tissue development and homeostasis, and its
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …

The collagen superfamily of proteins now contains at least 19 proteins formally defined as
collagens and an additional ten proteins that have collagen-like domains. The most …

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Defects in type IV collagen, a collagenous protein involved in the formation of basement
membranes, have been implicated in hereditary Alport's syndrome and acquired …

Four decades have passed since the first discovery of collagen IV by Kefalides in 1966.
Since then collagen IV has been investigated extensively by a large number of research …

Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes
and several homologous, CA-related proteins. All seven isozymes have been cloned …

Recent expert guidelines recommend genetic testing for the diagnosis of Alport syndrome.
Here, we describe current best practice and likely future developments. In individuals with …

The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour and
orchestrate functions of cells in tissue formation and homeostasis. The composition of the …

Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2)
constitute one of the most abundant components of nearly all basement membranes …