Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

D Li, D Dai, G Xiong, S Lan, C Zhang - Small, 2023 - Wiley Online Library
Most nanozymes in development for medical applications only exhibit single‐enzyme‐like
activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex …

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

G Yang, L Xu, Y Chao, J Xu, X Sun, Y Wu… - Nature …, 2017 - nature.com
Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is
developed for not only tumor microenvironment (TME)-specific imaging and on-demand …

[HTML][HTML] A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

X Zhang, J Tang, C Li, Y Lu, L Cheng, J Liu - Bioactive materials, 2021 - Elsevier
Photo-immunotherapy is a novel therapeutic approach against malignant tumors with
minimal invasiveness. Herein, a targeting multifunctional black phosphorus (BP) …

Oxygen-based nanocarriers to modulate tumor hypoxia for ameliorated anti-tumor therapy: fabrications, properties, and future directions

X Li, Y Wu, R Zhang, W Bai, T Ye… - Frontiers in Molecular …, 2021 - frontiersin.org
Over the past five years, oxygen-based nanocarriers (NCs) to boost anti-tumor therapy
attracted tremendous attention from basic research and clinical practice. Indeed, tumor …

Tumor microenvironment-responsive nanoparticle delivery of chemotherapy for enhanced selective cellular uptake and transportation within tumor

WC Huang, SH Chen, WH Chiang, CW Huang… - …, 2016 - ACS Publications
A novel drug delivery strategy featured with enhanced uptake of nanoparticles (NPs) by
targeted tumor cells and subsequent intratumoral cellular hitchhiking of chemotherapy to …

Advances in Nanoplatforms for Immunotherapy Applications Targeting the Tumor Microenvironment

N Zhang, J Zhou, S Li, W Cai, B Ru, J Hu… - Molecular …, 2024 - ACS Publications
Cancer immunotherapy is a treatment method that activates or enhances the autoimmune
response of the body to fight tumor growth and metastasis, has fewer toxic side effects and a …

How macrophages respond to two-dimensional materials: a critical overview focusing on toxicity

H Lin, Z Song, A Bianco - Journal of Environmental Science and …, 2021 - Taylor & Francis
With wider use of graphene-based materials and other two-dimensional (2 D) materials in
various fields, including electronics, composites, biomedicine, etc., 2 D materials can trigger …

Nanotechnology‐mediated photodynamic therapy: Focus on overcoming tumor hypoxia

K Moloudi, H Abrahamse… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
The oxygen level in the tumor is a critical marker that determines response to different
treatments. Cancerous cells can adapt to hypoxia and low pH conditions within the tumor …

One-pot synthesis-biocompatible copper–tripeptide complex as a nanocatalytic medicine to enhance chemodynamic therapy

ZE Hu, J Li, ZN Wu, YJ Wei, YH Liu… - … Science & Engineering, 2021 - ACS Publications
Chemodynamic therapy (CDT) is a kind of method utilizing hydroxyl radicals (• OH)
generated by Fenton or Fenton-like reactions in situ to kill tumor cells. Copper, a cofactor of …

Magnetic manganese oxide sweetgum-ball nanospheres with large mesopores regulate tumor microenvironments for enhanced tumor nanotheranostics

Y Feng, D Ding, W Sun, Y Qiu, L Luo… - … applied materials & …, 2019 - ACS Publications
An important objective of cancer nanomedicine is to improve the delivery efficacy of
functional agents to solid tumors for effective cancer imaging and therapy. Stimulus …