Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Immunomodulatory agents blocking the PD-1/PD-L1 pathway have shown a new way to
treat cancer. The explanation underlying the success of these agents may be the selective …

Sialic acid sugars are vital regulators of the immune system through binding to
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …

Undernutrition in children is a pressing global health problem, manifested in part by
impaired linear growth (stunting). Current nutritional interventions have been largely …

The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of
immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs …

Osteoporosis (OP) is a common age-related disease characterized by a deterioration of
bone mass and structure that predisposes patients to fragility fractures. Pharmaceutical …

Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and
regulate their cellular differentiation. Receptor activator for NF-κB ligand (RANKL or …

Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like
lectins. All Siglecs have at least two domains including an extracellular domain with variable …