Memory decline in aging results from multiple factors that influence both executive function
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …

Curiosity is a fundamental part of human motivation that supports a variety of human
intellectual behaviors ranging from early learning in children to scientific discovery …

Several tests from the CANTAB neuropsychological test battery previously shown to be
sensitive to frontal lobe dysfunction were administered to a large group of normal volunteers …

The density of striatal dopamine D2 receptors has been shown to vary considerably among
healthy subjects. 1 This variability might be due to genetic or environmental factors. In the …

The striatum acts in conjunction with the cortex to control and execute functions that are
impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and …

Positron emission tomography (PET) studies have revealed significant interindividual
variation in dopamine D 2 receptor density in vivo in human striatum. 1 Low D 2 receptor …

OBJECTIVE: The study examined the influence of losses in dopaminergic function on age-
related cognitive deficits. METHOD: Eleven healthy subjects (21–68 years of age) completed …

Loss of dopamine D2-like receptors in the striatum has been associated with both normal
human aging and impairment of cognitive and motor functions in the elderly. To investigate …

Five different methods for the estimation of the binding potential, a measure of Bmax/Kd, of
[11C] raclopride in human striatum were compared using data from a dose ranging study of …

Animal studies have indicated that the nigrostriatal dopaminergic system is involved in
central pain modulation. In a recent positron emission tomography (PET) study, we …