Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Traditionally, it has been held that a central characteristic of stem cells is their ability to
divide asymmetrically. Recent advances in inducible genetic labeling provided ample …

Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

Successful maintenance of cellular lineages critically depends on the fate decision
dynamics of stem cells (SCs) upon division. There are three possible strategies with respect …

In recent years cancer stem cells (CSCs) have been hypothesized to comprise only a minor
subpopulation in solid tumors that drives tumor initiation, progression, and metastasis; the so …

Tissue development and homeostasis are thought to be regulated endogenously by control
loops that ensure that the numbers of stem cells and daughter cells are maintained at …

The stem cell hypothesis suggests that there is a small group of malignant cells, the cancer
stem cells, that initiate the development of tumors, encourage its growth, and may even be …

In self-renewing tissues, cell lineages consisting of stem cell and classes of daughter cells
are the basic units which are responsible for the correct functioning of the organ. Cell …

Abstract Design principles of biological networks have been studied extensively in the
context of protein–protein interaction networks, metabolic networks, and regulatory …

Understanding the dynamics of stem cell lineages is of central importance both for healthy
and cancerous tissues. We study stochastic population dynamics of stem cells and …