[HTML][HTML] Anaemia and malaria
NJ White - Malaria journal, 2018 - Springer
Malaria is a major cause of anaemia in tropical areas. Malaria infection causes haemolysis
of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which …
of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
[HTML][HTML] Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
Background Development of an effective vaccine against the pathogenic blood-stage
infection of human malaria has proved challenging, and no candidate vaccine has affected …
infection of human malaria has proved challenging, and no candidate vaccine has affected …
The march toward malaria vaccines
SL Hoffman, J Vekemans, TL Richie, PE Duffy - Vaccine, 2015 - Elsevier
In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
Experimental infection of human volunteers
M Roestenberg, MA Hoogerwerf… - The Lancet Infectious …, 2018 - thelancet.com
Controlled human infection (CHI) trials, in which healthy volunteers are experimentally
infected, can accelerate the development of novel drugs and vaccines for infectious …
infected, can accelerate the development of novel drugs and vaccines for infectious …
[HTML][HTML] Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
TL Richie, PF Billingsley, BKL Sim, ER James… - Vaccine, 2015 - Elsevier
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
[HTML][HTML] Safety, immunogenicity, and protective efficacy against controlled human malaria infection of Plasmodium falciparum sporozoite vaccine in Tanzanian adults
SA Jongo, SA Shekalaghe, LWP Church… - The American journal …, 2018 - ncbi.nlm.nih.gov
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI)
of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ)(PfSPZ …
of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ)(PfSPZ …
Challenges and strategies for developing efficacious and long-lasting malaria vaccines
Although there has been major recent progress in malaria vaccine development, substantial
challenges remain for achieving highly efficacious and durable vaccines against …
challenges remain for achieving highly efficacious and durable vaccines against …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Controlled human malaria infection: applications, advances, and challenges
DI Stanisic, JS McCarthy, MF Good - Infection and immunity, 2018 - Am Soc Microbiol
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …