The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The
monoclonal antibody romosozumab binds to sclerostin and increases bone formation …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

Osteoporosis is a common disease characterised by a systemic impairment of bone mass
and microarchitecture that results in fragility fractures. With an ageing population, the …

Osteocytes, the most abundant cells in bone, have been long postulated to detect and
respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts …

Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This
review examines the fundamental pathogenetic mechanisms underlying this disorder, which …

Sclerostin, an osteocyte‐secreted protein, negatively regulates osteoblasts and inhibits
bone formation. In this first‐in‐human study, a sclerostin monoclonal antibody (AMG 785) …

Parathyroid hormone (PTH) exerts profound effects on skeletal homeostasis through
multiple cellular and molecular mechanisms. Continuous hyperparathyroidism causes net …