Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …

Abstract Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as
acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Drug-Induced Liver Injury The liver has a range of responses to drug-induced injury, with a
number of phenotypes. In addition, idiosyncratic reactions may occur as a consequence of …

Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice …

Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth
most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection …

The term acute liver failure (ALF) is frequently applied as a generic expression to describe
patients presenting with or developing an acute episode of liver dysfunction. In the context of …

Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …