Ionizing radiation interacts with the immune system in many ways with a multiplicity that
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …

Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

The human response to ionizing radiation (IR) varies among individuals. The first evidence
of the individual response to IR was reported in the beginning of the 20th century …

A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …

Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …

There is increasing evidence supporting the role of genetic variants in the development of
radiation-induced toxicity. However, previous candidate gene association studies failed to …

Background A total of 10%–20% of patients develop long-term toxicity following
radiotherapy for prostate cancer. Identification of common genetic variants associated with …

Purpose Several small studies have indicated that the ATM rs1801516 SNP is associated
with risk of normal tissue toxicity after radiotherapy. However, the findings have not been …

Radiation therapy has been used worldwide for many decades as a therapeutic regimen for
the treatment of different types of cancer. Just over 50% of cancer patients are treated with …