[HTML][HTML] In-host modeling

SM Ciupe, JM Heffernan - Infectious Disease Modelling, 2017 - Elsevier
Understanding the mechanisms governing host-pathogen kinetics is important and can
guide human interventions. In-host mathematical models, together with biological data, have …

Mathematical modeling of within‐host Zika virus dynamics

K Best, AS Perelson - Immunological reviews, 2018 - Wiley Online Library
Recent Zika virus outbreaks have been associated with severe outcomes, especially during
pregnancy. A great deal of effort has been put toward understanding this virus, particularly …

Influenza virus infection model with density dependence supports biphasic viral decay

AP Smith, DJ Moquin, V Bernhauerova… - Frontiers in …, 2018 - frontiersin.org
Mathematical models that describe infection kinetics help elucidate the time scales,
effectiveness, and mechanisms underlying viral growth and infection resolution. For …

Multiple cohort study of hospitalized SARS-CoV-2 in-host infection dynamics: Parameter estimates, identifiability, sensitivity and the eclipse phase profile

CS Korosec, MI Betti, DW Dick, HK Ooi… - Journal of Theoretical …, 2023 - Elsevier
Abstract Within-host SARS-CoV-2 modelling studies have been published throughout the
COVID-19 pandemic. These studies contain highly variable numbers of individuals and …

Principles governing establishment versus collapse of HIV-1 cellular spread

JM Hataye, JP Casazza, K Best, CJ Liang… - Cell host & …, 2019 - cell.com
A population at low census might go extinct or instead transition into exponential growth to
become firmly established. Whether this pivotal event occurs for a within-host pathogen can …

Initial inoculum and the severity of COVID-19: A mathematical modeling study of the dose-response of SARS-CoV-2 infections

B Fain, HM Dobrovolny - Epidemiologia, 2020 - mdpi.com
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes a variety of
responses in those who contract the virus, ranging from asymptomatic infections to acute …

Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective

S Vafadar, M Shahdoust, A Kalirad, P Zakeri… - PloS one, 2021 - journals.plos.org
Inspired by the competition exclusion principle, this work aims at providing a computational
framework to explore the theoretical feasibility of viral co-infection as a possible strategy to …

Incorporating Intracellular Processes in Virus Dynamics Models

SM Ciupe, JM Conway - Microorganisms, 2024 - mdpi.com
In-host models have been essential for understanding the dynamics of virus infection inside
an infected individual. When used together with biological data, they provide insight into …

Avian influenza viruses that cause highly virulent infections in humans exhibit distinct replicative properties in contrast to human H1N1 viruses

PF Simon, MA de La Vega, É Paradis, E Mendoza… - Scientific Reports, 2016 - nature.com
Avian influenza viruses present an emerging epidemiological concern as some strains of
H5N1 avian influenza can cause severe infections in humans with lethality rates of up to …

Duration of SHIV production by infected cells is not exponentially distributed: Implications for estimates of infection parameters and antiviral efficacy

CAA Beauchemin, T Miura, S Iwami - Scientific reports, 2017 - nature.com
The duration of the eclipse phase, from cell infection to the production and release of the first
virion progeny, immediately followed by the virus-production phase, from the first to the last …