Fentanyl is a key therapeutic, used in anaesthesia and pain management. It is also
increasingly used illicitly and is responsible for a large and growing number of opioid …

The only medication available currently to prevent and treat opioid overdose (naloxone) was
approved by the US Food and Drug Administration (FDA) nearly 50 years ago. Because of …

Opioid overdose is a leading cause of death in the United States. The only treatment
available currently is the competitive antagonist, naloxone (Narcan®). Although naloxone is …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Opioid use disorder affects over 2 million Americans with an increasing number of deaths
due to overdose from the synthetic opioid fentanyl and its analogs. The Food and Drug …

Methocinnamox (MCAM), a long-acting μ-opioid receptor antagonist, attenuates the positive
reinforcing effects of opioids, such as heroin and fentanyl, suggesting it could be an effective …

Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action,
attenuates heroin self-administration in rhesus monkeys, suggesting it could be an effective …

The opioid epidemic is an ongoing public health crisis, and the United States health system
is overwhelmed with increasing numbers of opioid-related overdoses. Methocinnamox …

Opioid overdose and opioid use disorder continue to be significant public health challenges
despite the availability of effective medications and significant efforts at all levels of society …

Rationale Opioid abuse remains a serious public health problem. The pseudoirreversible
mu opioid receptor antagonist methocinnamox (MCAM) might be useful for treating opioid …