p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

The tumor suppressor p53 plays various functional roles in the cell by regulating multiple
regulatory signals that ensure adequate temporal and spatial responses to cellular stress …

The p53 tumor suppressor protein is involved in regulating a wide variety of stress
responses, from senescence and apoptosis to more recently discovered roles in allowing …

Gankyrin is an ankyrin repeat oncoprotein commonly overexpressed in hepatocellular
carcinomas. Gankyrin interacts with the S6 proteasomal ATPase and accelerates the …

E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the
turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El …

The SCF (Skp1, Cullins, F-box proteins) multisubunit E3 ubiquitin ligase, also known as CRL
(Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the …

Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer
types, including disseminated and aggressive diseases in the palliative setting …

Heterochromatin is critical for proper centromere and telomere function, and it plays a key
role in the transcriptional silencing of specific genomic loci. In fission yeast, the Rik1 protein …

In response to DNA damage, cells activate a highly conserved and complex kinase-based
signaling network, commonly referred to as the DNA damage response (DDR), to safeguard …