Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

Background The development and persistence of addiction is mediated in part by drug-
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …

The developing brain is vulnerable to maternal bacterial and viral infections which induce
strong inflammatory responses in the mother that are mimicked in the offspring brain …

Long-term synaptic plasticity is widely believed to underlie learning and memory in the
brain. Whether plasticity is primarily expressed pre-or postsynaptically has been the subject …

Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an
important role in the regulation of neuronal excitability. However, little is known about a cell …

The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for
axon guidance during development and are expressed by neurons in the mature brain …