[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

[HTML][HTML] The emergence, genomic diversity and global spread of SARS-CoV-2

J Li, S Lai, GF Gao, W Shi - Nature, 2021 - nature.com
Since the first cases of COVID-19 were documented in Wuhan, China in 2019, the world has
witnessed a devastating global pandemic, with more than 238 million cases, nearly 5 million …

[HTML][HTML] Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

S Temmam, K Vongphayloth, E Baquero, S Munier… - Nature, 2022 - nature.com
The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related
viruses in Asian Rhinolophus bats,,–, including the closest virus from R. affinis, RaTG13 …

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …

[HTML][HTML] Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7

B Meng, SA Kemp, G Papa, R Datir, IATM Ferreira… - Cell reports, 2021 - cell.com
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70
in multiple independent lineages, often occurring after acquisition of receptor binding motif …

[HTML][HTML] Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

H Zhou, J Ji, X Chen, Y Bi, J Li, Q Wang, T Hu, H Song… - Cell, 2021 - cell.com
Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary
origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples …

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …

[HTML][HTML] ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

TN Starr, SK Zepeda, AC Walls, AJ Greaney… - Nature, 2022 - nature.com
Two different sarbecoviruses have caused major human outbreaks in the past two decades,.
Both of these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 through the …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

[PDF][PDF] Exploring the natural origins of SARS-CoV-2 in the light of recombination

S Lytras, J Hughes, D Martin… - Genome Biology and …, 2022 - academic.oup.com
The lack of an identifiable intermediate host species for the proximal animal ancestor of
SARS-CoV-2, and the large geographical distance between Wuhan and where the closest …