Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF)
binding and requires nucleosomal reorganization. However, it remains unclear how …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram
one type of cell into another. The transcription factors that reprogram cell fate are invariably …

During cell division, transcription factors (TFs) are removed from chromatin twice, during
DNA synthesis and during condensation of chromosomes. How TFs can efficiently find their …

Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …

Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of
genes that act as inhibitors of bone formation. How expression of bone-related miRs is …

During germ cell and preimplantation development, mammalian cells undergo nearly
complete reprogramming of DNA methylation patterns. We profiled the methylomes of …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …