Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

Histone deacetylases (HDACs) play an important role in regulating the expression of genes
involved in tumorigenesis and tumor maintenance, and hence they have been considered …

Phenotypic alterations in resident vascular cells contribute to the vascular remodeling
process in diseases such as pulmonary (arterial) hypertension [P (A) H]. How the molecular …

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …

Pulmonary hypertension is an enigmatic, deleterious disease driven by multiple
heterogeneous causes with a burgeoning proportion of older patients with complex, chronic …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Background. Heart failure is characterized by activation of the renin‐angiotensin‐
aldosterone system, which is involved in the regulation of cardiac hypertrophy and …

Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding
RNA, play a crucial role in the regulation of gene expression and are pivotal in biological …

Pulmonary arterial hypertension (PAH) is a devastating vascular disease with multiple
etiologies. Emerging evidence supports a fundamental role for epigenetic machinery and …

Chronic pulmonary hypertension (PH) is a fatal disease characterized by the persistent
activation of pulmonary vascular cells that exhibit aberrant expression of genes including …