Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury,
rather than a single disease, that is caused by diverse clinicopathological entities with …

Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …

Background Acute kidney injury is common, with a major effect on morbidity and health care
utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling …

Background Relatively high plasma levels of soluble urokinase-type plasminogen activator
receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor …

More than 85% of children and adolescents (majority between 1–12 years old) with
idiopathic nephrotic syndrome show complete remission of proteinuria following daily …

Thanks to remarkable advances in neonatal intensive care, infants who once had little
chance for survival can now enter adulthood. Yet the consequences of premature birth or …

Recurrence of focal segmental glomerulosclerosis (rFSGS) after kidney transplantation is a
cause of accelerated graft loss. To evaluate pathogenic antibodies (Abs) in rFSGS, we …

Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or
steroid-sparing agents. This open-label, noninferiority, randomized controlled trial at four …

Diabetic kidney disease (DKD) is the most common cause of ESRD in the United States.
Podocyte injury is an important feature of DKD that is likely to be caused by circulating …