Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

In this review, we discuss the connections between mitochondria and the gut microbiome
provided by reactive oxygen species (ROS). We examine the mitochondrion as an …

Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

Although the alternative oxidase, AOX, was known to be widespread in the animal kingdom
by 2004, its exact physiological role in animals remains poorly understood. Here we present …

Mitochondria are vital organelles for life in eukaryotes, taking centre stage in the process of
cellular respiration. This process is regulated via a series of finely coordinated obligate …

The maternal inheritance of mitochondrial genomes entails a sex-specific selective sieve,
whereby mutations in mitochondrial DNA can only respond to selection acting on females. In …

Nutrition is a primary determinant of health, but responses to nutrition vary with genotype.
Epistasis between mitochondrial and nuclear genomes may cause some of this variation …

The mitonuclear genome is the most successful co-evolved mutualism in the history of life on
Earth. The cross-talk between the mitochondrial and nuclear genomes has been shaped by …

In clinical settings, the benefit of statin for stroke is debatable as regular statin users may
suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis. Studies …

Mitochondria are central to both energy metabolism and biosynthesis. Mitochondrial function
could therefore influence resource allocation. Critically, mitochondrial function depends on …