Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI

P Nikolaou, AM Coffey, LL Walkup… - Proceedings of the …, 2013 - National Acad Sciences
The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129
(HP129Xe) make it attractive for a number of magnetic resonance applications; moreover …

Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy

AS Khan, RL Harvey, JR Birchall… - Angewandte Chemie …, 2021 - Wiley Online Library
Hyperpolarization is a technique that can increase nuclear spin polarization with the
corresponding gains in nuclear magnetic resonance (NMR) signals by 4–8 orders of …

129Xenon NMR: review of recent insights into porous materials

E Weiland, MA Springuel-Huet, A Nossov… - Microporous and …, 2016 - Elsevier
This paper presents a comprehensive review of the recent advances in xenon-129 nuclear
magnetic resonance (NMR) measurements. In the past thirty years, 129 Xe NMR has proved …

[HTML][HTML] Perspectives of hyperpolarized noble gas MRI beyond 3He

DML Lilburn, GE Pavlovskaya, T Meersmann - Journal of magnetic …, 2013 - Elsevier
Nuclear Magnetic Resonance (NMR) studies with hyperpolarized (hp) noble gases are at an
exciting interface between physics, chemistry, materials science and biomedical sciences …

XeNA: An automated 'open-source'129Xe hyperpolarizer for clinical use

P Nikolaou, AM Coffey, LL Walkup, BM Gust… - Magnetic resonance …, 2014 - Elsevier
Here we provide a full report on the construction, components, and capabilities of our
consortium's “open-source” large-scale (~ 1 L/h) 129 Xe hyperpolarizer for clinical, pre …

Temperature-Ramped 129Xe Spin-Exchange Optical Pumping

P Nikolaou, AM Coffey, MJ Barlow, MS Rosen… - Analytical …, 2014 - ACS Publications
We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an
automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key …

XeUS: A second-generation automated open-source batch-mode clinical-scale hyperpolarizer

JR Birchall, RK Irwin, P Nikolaou, AM Coffey… - Journal of Magnetic …, 2020 - Elsevier
We present a second-generation open-source automated batch-mode 129 Xe
hyperpolarizer (XeUS GEN-2), designed for clinical-scale hyperpolarized (HP) 129 Xe …

Observing and preventing rubidium runaway in a direct-infusion xenon-spin hyperpolarizer optimized for high-resolution hyper-CEST (chemical exchange saturation …

C Witte, M Kunth, F Rossella, L Schröder - The Journal of Chemical …, 2014 - pubs.aip.org
Xenon is well known to undergo host-guest interactions with proteins and synthetic
molecules. As xenon can also be hyperpolarized by spin exchange optical pumping …