The biology of regeneration failure and success after spinal cord injury

AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Diversity of astrocyte functions and phenotypes in neural circuits

BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …

Improved tools to study astrocytes

X Yu, J Nagai, BS Khakh - Nature Reviews Neuroscience, 2020 - nature.com
Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

The indispensable roles of microglia and astrocytes during brain development

K Reemst, SC Noctor, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

[HTML][HTML] Glia–neuron interactions in the mammalian retina

E Vecino, FD Rodriguez, N Ruzafa, X Pereiro… - Progress in retinal and …, 2016 - Elsevier
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

Gene expression elucidates functional impact of polygenic risk for schizophrenia

M Fromer, P Roussos, SK Sieberts, JS Johnson… - Nature …, 2016 - nature.com
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …

Elusive roles for reactive astrocytes in neurodegenerative diseases

L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

Astrocytes: biology and pathology

MV Sofroniew, HV Vinters - Acta neuropathologica, 2010 - Springer
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …

Heterogeneity of reactive astrocytes

MA Anderson, Y Ao, MV Sofroniew - Neuroscience letters, 2014 - Elsevier
Astrocytes respond to injury and disease in the central nervous system (CNS) with a process
referred to as reactive astrogliosis. Recent progress demonstrates that reactive astrogliosis …

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

W Niu, T Zang, Y Zou, S Fang, DK Smith, R Bachoo… - Nature cell …, 2013 - nature.com
Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-
restricted proliferating precursors in culture; however, this has not been demonstrated in …