The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Diversity of astrocyte functions and phenotypes in neural circuits
BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …
been viewed as simple, homogenous cells that serve the same essential supportive roles …
Improved tools to study astrocytes
Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …
including neurons, glial cells and blood vessels, and are involved or implicated in brain …
The indispensable roles of microglia and astrocytes during brain development
K Reemst, SC Noctor, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …
discuss the various roles of both microglia and astrocytes, and their interactions during brain …
[HTML][HTML] Glia–neuron interactions in the mammalian retina
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …
and the interactions of glia with blood vessels. Three main types of glial cells are found in …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Elusive roles for reactive astrocytes in neurodegenerative diseases
L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …
response. They become reactive in response to virtually all pathological situations in the …
Astrocytes: biology and pathology
MV Sofroniew, HV Vinters - Acta neuropathologica, 2010 - Springer
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
Heterogeneity of reactive astrocytes
MA Anderson, Y Ao, MV Sofroniew - Neuroscience letters, 2014 - Elsevier
Astrocytes respond to injury and disease in the central nervous system (CNS) with a process
referred to as reactive astrogliosis. Recent progress demonstrates that reactive astrogliosis …
referred to as reactive astrogliosis. Recent progress demonstrates that reactive astrogliosis …
In vivo reprogramming of astrocytes to neuroblasts in the adult brain
W Niu, T Zang, Y Zou, S Fang, DK Smith, R Bachoo… - Nature cell …, 2013 - nature.com
Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-
restricted proliferating precursors in culture; however, this has not been demonstrated in …
restricted proliferating precursors in culture; however, this has not been demonstrated in …