The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …

Importance Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive
statin therapy reduces progression of coronary atherosclerosis in proportion to achieved …

Over the last 3 decades there have been substantial improvements in treatments aimed at
reducing cardiovascular (CV) events. As these treatments have been developed, there have …

Atherosclerosis, chronic non-communicable diseases, and metabolic syndrome are highly
interconnected and collectively contribute to global health concerns that reduce life …

Background: Statins can regress coronary atheroma and lower clinical events. Although pre-
clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can …

In obese individuals, atherogenic dyslipidemia is a very common and important factor in the
increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized …

Objective To investigate the effects on cardiovascular outcomes of drug interventions that
increase high density lipoprotein levels. Design Meta-analysis. Studies reviewed …

Background Statins reduce adverse cardiovascular outcomes and slow the progression of
coronary atherosclerosis in proportion to their ability to reduce low-density lipoprotein (LDL) …

Background Inhibition of cholesteryl ester transfer protein (CETP) has been shown to have a
substantial effect on plasma lipoprotein levels. We investigated whether torcetrapib, a potent …