Protein phosphatase 1 is a key player in nuclear events
Reversible protein phosphorylation at serine (Ser), threonine (Thr) and tyrosine (Tyr)
residues is among the major regulatory mechanism in eukaryotic cells. The eukaryotic …
residues is among the major regulatory mechanism in eukaryotic cells. The eukaryotic …
Nuclear envelope dynamics during mammalian spermatogenesis: New insights on male fertility
The production of highly specialized spermatozoa from undifferentiated spermatogonia is a
strictly organized and programmed process requiring extensive restructuring of the entire …
strictly organized and programmed process requiring extensive restructuring of the entire …
In vitro cytotoxicity effects of zinc oxide nanoparticles on spermatogonia cells
Zinc Oxide Nanoparticles (ZnO NPs) are a type of metal oxide nanoparticle with an
extensive use in biomedicine. Several studies have focused on the biosafety of ZnO NPs …
extensive use in biomedicine. Several studies have focused on the biosafety of ZnO NPs …
Nuclear dynamics and chromatin structure: implications for pancreatic cancer
Changes in nuclear shape have been extensively associated with the dynamics and
functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and …
functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and …
Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1
The inner nuclear membrane is functionalized by diverse transmembrane proteins that
associate with nuclear lamins and/or chromatin. When cells enter mitosis, membrane …
associate with nuclear lamins and/or chromatin. When cells enter mitosis, membrane …
Nuclear accumulation of LAP1: TRF2 complex during DNA damage response uncovers a novel role for LAP1
Lamina-associated polypeptide 1 (LAP1) is a nuclear envelope (NE) protein whose function
remains poorly characterized. In a recent LAP1 protein interactome study, a putative …
remains poorly characterized. In a recent LAP1 protein interactome study, a putative …
Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation
M Santos, SC Domingues, P Costa, T Muller… - PLoS …, 2014 - journals.plos.org
Lamina associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear
membrane that is ubiquitously expressed. LAP1 binds to lamins and chromatin, probably …
membrane that is ubiquitously expressed. LAP1 binds to lamins and chromatin, probably …
[HTML][HTML] Quantitative proteome analysis of LAP1-deficient human fibroblasts: A pilot approach for predicting the signaling pathways deregulated in LAP1-associated …
CD Pereira, G Espadas, F Martins, AT Bertrand… - … and Biophysics Reports, 2024 - Elsevier
Abstract Lamina-associated polypeptide 1 (LAP1), a ubiquitously expressed nuclear
envelope protein, appears to be essential for the maintenance of cell homeostasis. Although …
envelope protein, appears to be essential for the maintenance of cell homeostasis. Although …
TOR1AIP1-Associated Nuclear Envelopathies
Human TOR1AIP1 encodes LAP1, a nuclear envelope protein expressed in most human
tissues, which has been linked to various biological processes and human diseases. The …
tissues, which has been linked to various biological processes and human diseases. The …
[HTML][HTML] LAP1 Interactome Profiling Provides New Insights into LAP1's Physiological Functions
CD Pereira, G Espadas, F Martins, AT Bertrand… - International Journal of …, 2024 - mdpi.com
The nuclear envelope (NE), a protective membrane bordering the nucleus, is composed of
highly specialized proteins that are indispensable for normal cellular activity. Lamina …
highly specialized proteins that are indispensable for normal cellular activity. Lamina …