Shc proteins are targets of activated tyrosine kinases and are implicated in the transmission
of activation signals to Ras. The p46shc and p52shc isoforms share a C‐terminal SH2 …

The Tpr-Met oncoprotein, which is a member of a family of tyrosine kinase oncoproteins
generated following genomic rearrangement, consists of the catalytic kinase domain of the …

The Met/Hepatocyte Growth Factor (HGF) receptor tyrosine kinase is oncogenically activated
through a rearrangement that creates a hybrid gene Tpr-Met. The resultant chimeric p65 Tpr …

Nrf2 transcription factor plays a crucial role in protection of cells against oxidative stress.
Under normal conditions Nrf2 is sequestered in cytoplasm by a cytoskeletal protein, Keapl …

Background: Signal transduction by growth factor receptor protein-tyrosine kinases is
generally initiated by autophosphorylation on tyrosine residues following ligand binding …

Activating germline mutations of the RET receptor tyrosine kinase are found in the majority of
cases of inherited cancer syndrome MEN 2, and inactivating mutations in some cases of …

Antigen receptors on T-and B-cells activate Ras through a signaling pathway that results in
the tyrosine phosphorylation of Shc and the formation of a complex of Shc with the Grb2 …

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct
phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N …

Shc proteins are important substrates of receptor and cytoplasmic tyrosine kinases that
couple activated receptors to downstream signaling enzymes. Phosphorylation of Shc …

Shc adaptor proteins play a role in linking activated cell surface receptors to the Ras
signaling pathway in response to receptor mediated tyrosine kinase activation. While the …