The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

Inactivation of the transcription factor p53, through either direct mutation or aberrations in
one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years …

The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

The TP 53 tumor suppressor gene is frequently inactivated in human tumors by missense
mutations in the DNA binding domain. TP 53 mutations lead to protein unfolding, decreased …

The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of
conformationally unstable p53 mutants because it has a unique surface crevice that can be …

Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in
the world. It is a heterogeneous disease characterized by genetic and epigenetic …

In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by
regulating the expression of genes critical for cancer prevention. Mutations in the gene …

Two main causes of platinum resistance are mutation in the tumor suppressor gene TP53
and drug-induced increase in intracellular glutathione concentration. Mutations in TP53 …

The tumour suppressor p53 is the most frequently mutated gene in human cancer.
Reactivation of mutant p53 by small molecules is an exciting potential cancer therapy …