High-throughput sequencing, also known as next-generation sequencing (NGS), has
revolutionized genomic research. In recent years, NGS technology has steadily improved …

Systematic characterization of the cancer microbiome provides the opportunity to develop
techniques that exploit non-human, microorganism-derived molecules in the diagnosis of a …

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable
tumour control and result in the long-term survival of patients with advanced cancers …

INTRODUCTION New therapies have been designed to stimulate the host's immune system
to fight cancer. Despite these exciting, recent successes, a large proportion of patients still …

Analysis of RNA-sequence (RNA-seq) data is widely used in transcriptomic studies and it
has many applications. We review RNA-seq data analysis from RNA-seq reads to the results …

Melanoma is currently divided on a genetic level according to mutational status. However,
this classification does not optimally predict prognosis. In prior studies, we have defined …

To investigate the role of gene expression in adaptation of marine ectotherms to different
temperatures, we examined the transcriptome‐wide thermal stress response in …

Specific mechanisms underlying gut microbiota alterations in schizophrenia remain
unknown. We aimed to compare gut microbiota between patients with schizophrenia and …

ABSTRACT In the United States, humans spend the majority of their time indoors, where
they are exposed to the microbiome of the built environment (BE) they inhabit. Despite the …

Quality control (QC) is a critical step in RNA sequencing (RNA-seq). Yet, it is often ignored or
conducted on a limited basis. Here, we present a multi-perspective strategy for QC of RNA …