Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond

MD Parkins, BE Lee, N Acosta, M Bautista… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Wastewater-based surveillance (WBS) has undergone dramatic advancement in the context
of the coronavirus disease 2019 (COVID-19) pandemic. The power and potential of this …

Wastewater-based detection of two influenza outbreaks

MK Wolfe, D Duong, KM Bakker… - … & Technology Letters, 2022 - ACS Publications
Traditional influenza surveillance informs control strategies but can lag behind outbreak
onset and undercount cases. Wastewater surveillance is effective for monitoring near real …

[HTML][HTML] Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic …

AB Boehm, B Hughes, D Duong, V Chan-Herur… - The Lancet …, 2023 - thelancet.com
Background Respiratory disease is a major cause of morbidity and mortality; however,
surveillance for circulating respiratory viruses is passive and biased. Wastewater-based …

[HTML][HTML] Show us the data: global COVID-19 wastewater monitoring efforts, equity, and gaps

CC Naughton, FA Roman, AGF Alvarado… - FEMS …, 2023 - academic.oup.com
A year since the declaration of the global coronavirus disease 2019 (COVID-19) pandemic,
there were over 110 million cases and 2.5 million deaths. Learning from methods to track …

Does normalization of SARS-CoV-2 concentrations by Pepper Mild Mottle Virus improve correlations and lead time between wastewater surveillance and clinical data …

R Maal-Bared, Y Qiu, Q Li, T Gao, SE Hrudey… - Science of The Total …, 2023 - Elsevier
Wastewater-based surveillance (WBS) data normalization is an analyte measurement
correction that addresses variations resulting from dilution of fecal discharge by non-sanitary …

Respiratory syncytial virus (RSV) RNA in wastewater settled solids reflects RSV clinical positivity rates

B Hughes, D Duong, BJ White… - … & Technology Letters, 2022 - ACS Publications
Wastewater-based epidemiology (WBE) uses concentrations of infectious agent targets in
wastewater to infer infection trends in the contributing community. To date, WBE has been …

[HTML][HTML] Evaluation of process limit of detection and quantification variation of SARS-CoV-2 RT-qPCR and RT-dPCR assays for wastewater surveillance

W Ahmed, A Bivins, S Metcalfe, WJM Smith… - Water Research, 2022 - Elsevier
Effective wastewater surveillance of SARS-CoV-2 RNA requires the rigorous
characterization of the limit of detection resulting from the entire sampling process-the …

[HTML][HTML] Human viral nucleic acids concentrations in wastewater solids from Central and Coastal California USA

AB Boehm, MK Wolfe, KR Wigginton, A Bidwell… - Scientific data, 2023 - nature.com
We measured concentrations of SARS-CoV-2, influenza A and B virus, respiratory syncytial
virus (RSV), mpox virus, human metapneumovirus, norovirus GII, and pepper mild mottle …

Detection of SARS-CoV-2 variants Mu, Beta, Gamma, Lambda, Delta, Alpha, and Omicron in wastewater settled solids using mutation-specific assays is associated …

M Wolfe, B Hughes, D Duong… - Applied and …, 2022 - Am Soc Microbiol
Changes in the circulation of SARS-CoV-2 variants of concern (VOCs) may require changes
in the public health response to the COVID-19 pandemic, as they have the potential to …

[HTML][HTML] Human norovirus (HuNoV) GII RNA in wastewater solids at 145 United States wastewater treatment plants: comparison to positivity rates of clinical specimens …

AB Boehm, MK Wolfe, BJ White, B Hughes… - Journal of Exposure …, 2023 - nature.com
Abstract Background Human norovirus (HuNoV) is a leading cause of disease globally, yet
actual incidence is unknown. HuNoV infections are not reportable in the United States, and …