Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that
play essential roles in many cellular processes involved in the control of the cell cycle …

ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

Protein–protein interaction is one of the key events in the signal transduction pathway. The
interaction changes the conformations, activities, localization and stabilities of the proteins …

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We
designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting …

Transition metal catalysts (TMCs) mediated bioorthogonal catalysis expand the chemical
possibilities within cells. Developing synthetic TMCs tools that emulate the efficiency and …

The polo‐box domain (PBD) of PLK1 determines mitotic substrate recognition and
subcellular localization. Compounds that target PLK1 selectively are required due to the …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Due to
often unspecific disease symptoms, locally advanced or metastatic disease is diagnosed in …

Abstract Polo‐like kinase 1 (Plk1), a validated cancer target, harbors a protein–protein
interaction domain referred to as the polo‐box domain (PBD), in addition to its enzymatic …

Abstract Polo‐like kinase 1 (Plk1), a key player in mitosis, is overexpressed in a wide range
of tumor types and has been validated as a target for tumor therapy. In addition to its N …