Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS
In spite of significant advances in antiretroviral (ARV) therapy, the elimination of human
immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system …
immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system …
[HTML][HTML] In vivo excision of HIV-1 provirus by saCas9 and multiplex single-guide RNAs in animal models
CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure
for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome …
for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome …
Elimination of HIV-1 genomes from human T-lymphoid cells by CRISPR/Cas9 gene editing
We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …
entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA …
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
A CRISPR/Cas9 gene editing strategy has been remarkable in excising segments of
integrated HIV-1 DNA sequences from the genome of latently infected human cell lines and …
integrated HIV-1 DNA sequences from the genome of latently infected human cell lines and …
CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
[HTML][HTML] Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
S Najafi, SC Tan, S Aghamiri, P Raee… - Biomedicine & …, 2022 - Elsevier
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
Class 2 CRISPR/Cas: an expanding biotechnology toolbox for and beyond genome editing
Y Tang, Y Fu - Cell & bioscience, 2018 - Springer
Artificial nuclease-dependent DNA cleavage systems (zinc-finger nuclease, ZFN;
transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems …
transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems …
Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection
CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency
virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a …
virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a …
Gene editing of HIV-1 co-receptors to prevent and/or cure virus infection
Antiretroviral therapy has prolonged the lives of people living with human immunodeficiency
virus type 1 (HIV-1), transforming the disease into one that can be controlled with lifelong …
virus type 1 (HIV-1), transforming the disease into one that can be controlled with lifelong …