COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death
globally, and manifests as a progressive inflammatory lung disease with no curative …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …

Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …

Although it is well accepted that air pollution exposure exacerbates preexisting airway
disease, it has not been firmly established that long-term pollution exposure increases the …

Highlights•Transition from conventional 2D models to 3D and advanced lung-on-a-chip
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …

ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …