Lichens: a promising source of antibiotic and anticancer drugs

G Shrestha, LL St. Clair - Phytochemistry reviews, 2013 - Springer
Lichens are symbiotic associations between fungi and a photosynthetic alga and/or
cyanobacteria. Lichenized fungi have been found to produce a wide array of secondary …

Advances in research on bioactivity, toxicity, metabolism, and pharmacokinetics of usnic acid in vitro and in vivo

H Wang, M Xuan, C Huang, C Wang - Molecules, 2022 - mdpi.com
Lichens are among the most widely distributed plants on earth and have the longest growth
cycle. Usnic acid is an abundant characteristic secondary metabolite of lichens and the …

Lichens as a potential source of bioactive secondary metabolites

B Ranković, M Kosanić - Lichen secondary metabolites: bioactive …, 2019 - Springer
Lichens are complex symbiotic associations between fungi and algae which are important
constituents of many ecosystems. The production of various unique extracellular secondary …

Evernia prunastri and Pseudoevernia furfuraceae lichens and their major metabolites as antioxidant, antimicrobial and anticancer agents

M Kosanić, N Manojlović, S Janković… - Food and chemical …, 2013 - Elsevier
The aim of this study is to investigate chemical composition of acetone extracts of the lichens
Evernia prunastri and Pseudoevernia furfuraceae and in vitro antioxidant, antimicrobial, and …

Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid

M Bačkorová, M Bačkor, J Mikeš, R Jendželovský… - Toxicology in vitro, 2011 - Elsevier
One of the ways for searching for potentially new anti-cancer drugs is the testing of various
naturally synthesized compounds. Lichens are a source of unique chemical agents of which …

Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines

M Bačkorová, R Jendželovský, M Kello, M Bačkor… - Toxicology in vitro, 2012 - Elsevier
Lichens are a known source of approximately 800 unique secondary metabolites, many of
which play important ecological roles, including regulating the equilibrium between …

Hormesis: Wound healing and keratinocytes

EJ Calabrese, G Dhawan, R Kapoor… - Pharmacological …, 2022 - Elsevier
Hormetic dose responses (ie, a biphasic dose/concentration response characterized by a
low dose stimulation and a high dose inhibition) are shown herein to be commonly reported …

Chemical composition of three Parmelia lichens and antioxidant, antimicrobial and cytotoxic activities of some their major metabolites

N Manojlović, B Ranković, M Kosanić, P Vasiljević… - Phytomedicine, 2012 - Elsevier
The aim of this study is to investigate chemical composition of acetone extracts of the lichens
Parmelia caperata, P. saxatilis and P. sulcata and antioxidant, antimicrobial and anticancer …

Cytotoxic Activity and Antioxidant Capacity of Purified Lichen Metabolites: An In Vitro Study

F Brisdelli, M Perilli, D Sellitri, M Piovano… - Phytotherapy …, 2013 - Wiley Online Library
The purpose of this study was to investigate the effects of six lichen metabolites (diffractaic
acid, lobaric acid, usnic acid, vicanicin, variolaric acid, protolichesterinic acid) on …

Bioactive lichen metabolites: alpine habitats as an untapped source

J Boustie, S Tomasi, M Grube - Phytochemistry Reviews, 2011 - Springer
Lichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific
metabolites. Some of these are forming an available biomass for phytochemical …