Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Background Cilia are complex and powerful cellular structures of the respiratory mucosa that
play a critical role in airway defense. Respiratory epithelium is lined with cilia that perform an …

Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues,
including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and
plays an essential role in goblet cell mucus production from the respiratory tract epithelium …

Membrane lipid rafts are distinct plasma membrane nanodomains that are enriched with
cholesterol, sphingolipids and gangliosides, with occasional presence of saturated fatty …

Rationale: Asthma is a chronic inflammatory disorder with a characteristic of airway
hyperresponsiveness (AHR). Ca2+-activated Cl−[Cl (Ca)] channels are inferred to be …

Background: The incidence of respiratory diseases and the respiratory disease mortality rate
have increased in recent years. Recent studies have shown that long non-coding RNA …

Heavily glycosylated secreted mucin MUC5AC, by the virtue of its cysteine-rich repeats, can
form inter-and intramolecular disulfide linkages resulting in complex polymers, which in turn …

Airway mucus has a key role in protective innate immune responses, but excessive mucus
production and secretion in proximal and in distal airways are associated with disabling …