Platelet-derived drug delivery systems: pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond

Y Zhu, L Xu, Y Kang, Q Cheng, Y He, X Ji - Biomaterials, 2024 - Elsevier
Platelets play a critical role as circulating cells in the human body and contribute to essential
physiological processes such as blood clotting, hemostasis, vascular repair, and thrombus …

Platelet-rich plasma in dermatology: new insights on the cellular mechanism of skin repair and regeneration

CG Manole, C Soare, LC Ceafalan, VM Voiculescu - Life, 2023 - mdpi.com
The skin's recognised functions may undergo physiological alterations due to ageing,
manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume …

[HTML][HTML] Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury

D Livkisa, TH Chang, T Burnouf, A Czosseck, NTN Le… - Biomaterials, 2024 - Elsevier
Extracellular vesicles (EVs) from cultured cells or bodily fluids have been demonstrated to
show therapeutic value following myocardial infarction. However, challenges in donor …

The Core‐Shell Microneedle with Probiotic Extracellular Vesicles for Infected Wound Healing and Microbial Homeostasis Restoration

F Qi, Y Xu, B Zheng, Y Li, J Zhang, Z Liu, X Wang… - Small, 2024 - Wiley Online Library
Wound healing is a dynamic process involving the timely transition of organized phases.
However, infected wounds often experience prolonged inflammation due to microbial …

Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine

M Brittberg - Journal of Experimental Orthopaedics, 2024 - Wiley Online Library
Intact articular cartilage plays a vital role in joint homeostasis. Local cartilage repairs, where
defects in the cartilage matrix are filled in and sealed to congruity, are therefore important …

Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models

L Delila, O Nebie, NTN Le, K Timmerman… - Journal of Biomedical …, 2024 - Springer
The burgeoning field of regenerative medicine has significantly advanced with recent
findings on biotherapies using human platelet lysates (HPLs), derived from clinical-grade …

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Y Qiu, G Lu, N Li, Y Hu, H Tan, C Jiang - Frontiers in Immunology, 2024 - frontiersin.org
Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the
gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment …

The value of platelet-rich plasma-derived extracellular vesicles in modern medicine

Y Hou, X Wen, L Zhou, X Fang - Annals of Medicine, 2023 - Taylor & Francis
Platelet-rich plasma (PRP) has been widely used in clinical practice. The mechanism by
which PRP promotes tissue repair lies in the release of multiple growth factors upon platelet …

Fibrinogen binding to activated platelets and its biomimetic thrombus-targeted thrombolytic strategies

Y Huang, J Wang, Y Guo, L Shen, Y Li - International Journal of Biological …, 2024 - Elsevier
Thrombosis is associated with various fatal arteriovenous syndromes including ischemic
stroke, myocardial infarction, and pulmonary embolism. However, current clinical …

Sequential management of burn wound healing stages through biointelligence-inspired platelet extracellular vesicle-encapsulated photodynamic diferuloylmethane

AEY Chuang, YL Chen, HT Nguyen, HT Lu, CH Liu - Nanoscale, 2024 - pubs.rsc.org
The process of wound healing is a complex, multi-phase phenomenon crucial for optimal
tissue regeneration. Traditional drug delivery systems often target specific phases of wound …