Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

Bisulfite sequencing detects 5mC and 5hmC at single-base resolution. However, bisulfite
treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing …

Cytosine base editors (CBEs) enable targeted C• G-to-T• A conversions in genomic DNA.
Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide …

Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …

Several mutations are required for cancer development, and genome sequencing has
revealed that many cancers, including breast cancer, have somatic mutation spectra …

Base editors (BEs) enable the generation of targeted single-nucleotide mutations, but
currently used rat APOBEC1-based BEs are relatively inefficient in editing cytosines in …

Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a bisulfite-free
method for localizing 5-hydroxymethylcytosine (5hmC) at single-base resolution with low …

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …