Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
K Chamoto, T Yaguchi, M Tajima, T Honjo - Nature Reviews …, 2023 - nature.com
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
Defining memory CD8 T cell
MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …
cells differing in phenotype and function. This review will focus on our current understanding …
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex)
T cells. These developmental pathways are associated with distinct transcriptional and …
T cells. These developmental pathways are associated with distinct transcriptional and …
[HTML][HTML] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
cBAF complex components and MYC cooperate early in CD8+ T cell fate
The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy
L Huang, Y Li, Y Du, Y Zhang, X Wang, Y Ding… - Nature …, 2019 - nature.com
One of the main challenges for immune checkpoint blockade antibodies lies in malignancies
with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of …
with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of …
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
BD Choi, X Yu, AP Castano, AA Bouffard… - Nature …, 2019 - nature.com
Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …
Nanoparticle‐enhanced radiotherapy to trigger robust cancer immunotherapy
External radiotherapy is extensively used in clinic to destruct tumors by locally applied
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …
Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the …
[HTML][HTML] The diversity of gut microbiome is associated with favorable responses to anti–programmed death 1 immunotherapy in Chinese patients with NSCLC
Y Jin, H Dong, L Xia, Y Yang, Y Zhu, Y Shen… - Journal of Thoracic …, 2019 - Elsevier
Introduction Gut microbiome affecting the responses to immune checkpoint inhibitors against
advanced NSCLC has been investigated in the Western population. However, considering …
advanced NSCLC has been investigated in the Western population. However, considering …