Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting
Lung cancer remains the leading cause of cancer-related deaths despite recent
breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has …
breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has …
Targeting the mitochondria in chronic respiratory diseases
DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …
the source of respiratory ATP. Recently published studies have demonstrated that …
[HTML][HTML] Mechanism of action for HDAC inhibitors—insights from omics approaches
W Li, Z Sun - International journal of molecular sciences, 2019 - mdpi.com
Histone deacetylase inhibitors (HDIs) are a class of prominent epigenetic drugs that are
currently being tested in hundreds of clinical trials against a variety of diseases. A few …
currently being tested in hundreds of clinical trials against a variety of diseases. A few …
Epigenetic events involved in organic cation transporter 1‐dependent impaired response of hepatocellular carcinoma to sorafenib
R Al‐Abdulla, E Lozano, RIR Macias… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose The expression of the human organic cation transporter‐1
(hOCT1, gene SLC22A1) is reduced in hepatocellular carcinoma (HCC). The molecular …
(hOCT1, gene SLC22A1) is reduced in hepatocellular carcinoma (HCC). The molecular …
[HTML][HTML] Histone deacetylases modulate resistance to the therapy in lung cancer
E Contreras-Sanzón, H Prado-Garcia… - Frontiers in …, 2022 - frontiersin.org
The acetylation status of histones located in both oncogenes and tumor suppressor genes
modulate cancer hallmarks. In lung cancer, changes in the acetylation status are associated …
modulate cancer hallmarks. In lung cancer, changes in the acetylation status are associated …
[HTML][HTML] The Synergistic Antitumor Effect of Decitabine and Vorinostat Combination on HepG2 Human Hepatocellular Carcinoma Cell Line via Epigenetic Modulation …
Hepatocellular carcinoma (HCC) is a worldwide health issue. Epigenetic alterations play a
crucial role in HCC tumorigenesis. Using epigenetic modulators for HCC treatment confers a …
crucial role in HCC tumorigenesis. Using epigenetic modulators for HCC treatment confers a …
[HTML][HTML] BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin-and MGMT-dependent apoptotic cell …
HJ Ko, SJ Chiou, CY Tsai, JK Loh, XY Lin… - Cell Communication and …, 2022 - Springer
Background Despite advances in treatment, patients with refractory colorectal cancer (CRC)
still have poor long-term survival, so there is a need for more effective therapeutic options …
still have poor long-term survival, so there is a need for more effective therapeutic options …
[HTML][HTML] Negative regulators of Wnt signaling in non-small cell lung cancer: Theoretical basis and therapeutic potency
Z Song, H Wang, S Zhang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Significant advances in the treatment of non-small cell lung cancer (NSCLC) have been
made over the past decade, and they predominantly involve molecular targets such as …
made over the past decade, and they predominantly involve molecular targets such as …
Histone deacetylase inhibitors as a potential new treatment for psoriatic disease and other inflammatory conditions
JM Nazri, K Oikonomopoulou… - Critical Reviews in …, 2023 - Taylor & Francis
Collectively known as psoriatic disease, psoriasis and psoriatic arthritis (PsA) are immune-
mediated inflammatory diseases in which patients present with cutaneous and …
mediated inflammatory diseases in which patients present with cutaneous and …
[HTML][HTML] Comparison of DNA demethylating and histone deacetylase inhibitors hydralazine-valproate versus vorinostat-decitabine incutaneous t-cell lymphoma in …
A Schcolnik-Cabrera… - American journal of …, 2018 - ncbi.nlm.nih.gov
Purpose: Cutaneous T-cell lymphoma (CTCL) is an uncommon extranodal non-Hodgkin T-
cell lymphoma that originates from mature T lymphocytes homed at the skin. Epigenetic …
cell lymphoma that originates from mature T lymphocytes homed at the skin. Epigenetic …