Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Physiological evidence supporting the role of the adenine nucleotide, ATP 1 (Figure 1), as a
neurotransmitter was first summarized in detail in 1972, 1 representing the basis of …

The field of hemichannels is closely related to the purinergic signaling and both areas have
been growing in parallel. Hemichannels open in response to a wide range of stressful …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …

P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation
channels with two transmembrane domains, intracellular amino and carboxy termini and a …

Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …

P2X receptors for ATP are expressed throughout the body and mediate a multitude of
functions, including muscle contraction, neuronal excitability and bone formation. In the mid …