Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
Exploring the mechanical perspective of a new anti-tumor agent: melatonin
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …
Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru (ii)-p-cymene complexes with acylthiourea ligands—in vitro and in vivo …
Six different acylthiourea ligands (L1–L6) and their corresponding Ru (II)-p-cymene
complexes (P1–P6) were designed to explore the structure–activity relationship of the …
complexes (P1–P6) were designed to explore the structure–activity relationship of the …
Synthesis, molecular docking, and biological evaluation of novel anthranilic acid hybrid and its diamides as antispasmodics
The present article focuses on the synthesis and biological evaluation of a novel anthranilic
acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico …
acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico …
Current scenario of pyrazole hybrids with in vivo therapeutic potential against cancers
Z Xu, Y Zhuang, Q Chen - European Journal of Medicinal Chemistry, 2023 - Elsevier
Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …
the prevalence and mortality rates of cancer remain high. The drug resistance and low …
Novel anthranilic acid hybrids—An alternative weapon against inflammatory diseases
Anti-inflammatory drugs are used to relieve pain, fever, and inflammation while protecting
the cardiovascular system. However, the side effects of currently available medications have …
the cardiovascular system. However, the side effects of currently available medications have …
Medicinal chemistry of anthranilic acid derivatives: A mini review
P Prasher, M Sharma - Drug Development Research, 2021 - Wiley Online Library
Anthranilic acid and its analogues present a privileged profile as pharmacophores for the
rational development of pharmaceuticals deliberated for managing the pathophysiology and …
rational development of pharmaceuticals deliberated for managing the pathophysiology and …
Synthesis of new imidazole-triazole-glycoside hybrids as anti-breast cancer candidates
WI El-Sofany, WA El-sayed, AA Abd-Rabou… - Journal of Molecular …, 2022 - Elsevier
One of the leading causes of death worldwide among women is breast cancer. Thus,
discovering new multi-target anti-breast cancer drugs is mandatory to stimulate nitric oxide …
discovering new multi-target anti-breast cancer drugs is mandatory to stimulate nitric oxide …
Anticancer phytochemical-based nanoformulations: therapeutic intervention in cancer cell lines
Phytochemicals have the potential to treat resistant cancer. They are delivered to the target
site via nano-based carriers. Promising results are seen in preclinical and in vitro models, as …
site via nano-based carriers. Promising results are seen in preclinical and in vitro models, as …
Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents
The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …