Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …

Microsporidia are a large group of fungal‐related obligate intracellular parasites. They are
responsible for infections in humans as well as in agriculturally and environmentally …

Upon sensing viral RNA, mammalian RIG-I-like receptors (RLRs) activate downstream
signals using caspase activation and recruitment domains (CARDs), which ultimately …

The nematode Caenorhabditis elegans has been a model for studying infection since the
early 2000s and many major discoveries have been made regarding its innate immune …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

Intestinal epithelial cells are subject to attack by a diverse array of microbes, including
intracellular as well as extracellular pathogens. While defense in epithelial cells can be …

Defense against intracellular infection has been extensively studied in vertebrate hosts, but
less is known about invertebrate hosts; specifically, the transcription factors that induce …

Although the type‐I interferon (IFN‐I) response is considered vertebrate‐specific, recent
findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis …

Coordination of cellular responses to stress is essential for health across the lifespan. The
transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing …

Parental infection can result in the production of offspring with enhanced immunity
phenotypes. Critically, the mechanisms underlying inherited immunity are poorly …